Drug Resistance
Preventing drugs from being transported

Certain membrane proteins specialise in transporting molecules out of cells – a problem for the efficacy of cancer medication and antibiotics

An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment. The transport proteins, called ABC exporters, are present, for instance, in the cell membranes of bacteria and in large quantities in cancer cells. They are responsible for transporting small modules out of the cells. Some transporters can pump antibiotics or chemotherapy agents out of the cells, thus rendering therapies ineffective.

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